Ontology highlight
ABSTRACT:
SUBMITTER: Proietti I
PROVIDER: S-EPMC7600801 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Proietti Ilaria I Skroza Nevena N Bernardini Nicoletta N Tolino Ersilia E Balduzzi Veronica V Marchesiello Anna A Michelini Simone S Volpe Salvatore S Mambrin Alessandra A Mangino Giorgio G Romeo Giovanna G Maddalena Patrizia P Rees Catherine C Potenza Concetta C
Cancers 20200929 10
This systematic review investigated the literature on acquired v-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitor resistance in patients with melanoma. We searched MEDLINE for articles on BRAF inhibitor resistance in patients with melanoma published since January 2010 in the following areas: (1) genetic basis of resistance; (2) epigenetic and transcriptomic mechanisms; (3) influence of the immune system on resistance development; and (4) combination therapy to overcome resistance. C ...[more]