The Relevance of Selenium Status in Rheumatoid Arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained.

SUBMITTER: Turrubiates-Hernandez FJ 

PROVIDER: S-EPMC7601319 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature