Electrospun Fibres with Hyaluronic Acid-Chitosan Nanoparticles Produced by a Portable Device.

ABSTRACT: Electrospinning is a versatile technique to produce nano/microscale fibrous scaffolds for tissue engineering and drug delivery applications. This research aims to demonstrate that hyaluronic acid-chitosan (HA-CS) nanoparticles can be electrospun together with polycaprolactone (PCL) and gelatine (Ge) fibres using a portable device to create scaffolds for tissue repair. A range of polymer solutions of PCL-gelatine at different weight/volume concentrations and ratios were electrospun and characterised. Fibre-cell interaction (F11 cells) was evaluated based on cell viability and proliferation and, from here, a few polymer blends were electrospun into random or aligned fibre arrangements. HA-CS nanoparticles were synthesised, characterised, and used to functionalise electrospun fibres (8% w/v a

SUBMITTER: Fuenteslopez CV 

PROVIDER: S-EPMC7601987 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature