Ontology highlight
ABSTRACT:
SUBMITTER: Ambrosio L
PROVIDER: S-EPMC7602517 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ambrosio Leanne L Argenziano Monica M Cucci Marie Angèle MA Grattarola Margherita M de Graaf Inge A M IAM Dianzani Chiara C Barrera Giuseppina G Sánchez Nieves Javier J Gomez Rafael R Cavalli Roberta R Pizzimenti Stefania S
Antioxidants (Basel, Switzerland) 20201014 10
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as the master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a pivotal role in cancer progression. Nrf2 mediates the adaptive response which contributes to the resistance to chemotherapeutic pro-oxidant drugs, such as cisplatin (CDDP), in various tumors, including bladder cancers. For this reason, Nrf2 could be a promising target to overcome chemoresistance. There are sever ...[more]