Ontology highlight
ABSTRACT:
SUBMITTER: Jendryczko K
PROVIDER: S-EPMC7602595 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Jendryczko Karolina K Chudzian Julia J Skinder Natalia N Opaliński Łukasz Ł Rzeszótko Jakub J Wiedlocha Antoni A Otlewski Jacek J Szlachcic Anna A
Cancers 20201015 10
Fibroblast growth factor receptors (FGFRs) are emerging targets for directed cancer therapy. Presented here is a new FGFR1-targeting conjugate, the peptibodyF2, which employs peptibody, a fusion of peptide and the Fc fragment of human IgG as a selective targeting agent and drug carrier. Short peptide based on FGF2 sequence was used to construct a FGFR1-targeting peptibody. We have shown that this peptide ensures specific delivery of peptibodyF2 into FGFR1-expressing cells. In order to use peptib ...[more]