Ontology highlight
ABSTRACT:
SUBMITTER: Reig-Lopez J
PROVIDER: S-EPMC7602742 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Reig-López Javier J Maldonado María Del Mar MDM Merino-Sanjuan Matilde M Cruz-Collazo Ailed M AM Ruiz-Calderón Jean F JF Mangas-Sanjuán Victor V Dharmawardhane Suranganie S Duconge Jorge J
Pharmaceutics 20201015 10
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based pharmacokinetic/pharmacodynamic (PBPK-PD) model of MBQ-167 to predict tumor growth inhibition following intraperitoneal (IP) administration in mice bearing Triple Negative and HER2+ mammary tumors. PBP ...[more]