Ontology highlight
ABSTRACT:
SUBMITTER: Asouri M
PROVIDER: S-EPMC7603253 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Asouri Mohsen M Alinejad Rokni Hamid H Sahraian Mohammad Ali MA Fattahi Sadegh S Motamed Nima N Doosti Rozita R Rahimi Hamzeh H Lotfi Maryam M Moslemi Azam A Karimpoor Morteza M Mahboudi Fereidoun F Akhavan-Niaki Haleh H
Reports of biochemistry & molecular biology 20200701 2
<h4>Background</h4>Multiple sclerosis (MS) is a common demyelinating neurodegenerative disorder with significant heritability. Previous studies have associated genetic variants in human leukocyte antigen <i>(HLA)</i> complex, <i>IL2RA</i> , and <i>HMGB1</i> genes with the pathophysiology of MS.<h4>Methods</h4>In order to investigate the gene association in the Iranian population, we performed a genotyping study of 36 variants in the mentioned genes using Sanger sequencing in 102 MS patients and ...[more]