A Novel Signature of 23 Immunity-Related Gene Pairs Is Prognostic of Cutaneous Melanoma.
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ABSTRACT:
SUBMITTER: Xue YN
PROVIDER: S-EPMC7604355 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
A Novel Signature of 23 Immunity-Related Gene Pairs Is Prognostic of Cutaneous Melanoma.
Xue Ya-Nan YN Xue Yi-Nan YN Wang Zheng-Cai ZC Mo Yong-Zhen YZ Wang Pin-Yan PY Tan Wei-Qiang WQ
Frontiers in immunology 20201019
In this study, we aimed to identify an immune-related signature for predicting prognosis in cutaneous melanoma (CM). Sample data from The Cancer Genome Atlas (TCGA; n = 460) were used to develop a prognostic signature with 23 immune-related gene pairs (23 IRGPs) for CM. Patients were divided into high- and low-risk groups using the TCGA and validation datasets GSE65904 (n = 214), GSE59455 (n = 141), and GSE22153 (n = 79). The ability of the 23-IRGP signature to predict CM was precise, with the s ...[more]
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