Ontology highlight
ABSTRACT:
SUBMITTER: Kuhle J
PROVIDER: S-EPMC7604552 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Multiple sclerosis (Houndmills, Basingstoke, England) 20191104 13
<h4>Background</h4>Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive value for long-term clinical outcomes remains unclear.<h4>Objective</h4>We measured NfL from a phase 3 trial in relapsing-remitting MS and investigated its association with outcomes after 8 and 15 years.<h4>Methods</h4>NfL concentrations were measured by single molecule array assay in cerebrospinal fluid (CSF) from MS patients (<i>n</ ...[more]