Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC7605547 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
JCI insight 20201015 20
Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that are involved in a variety of human disorders, including cancer and autoimmune diseases. Although targeting PAD4 has shown no benefit in sepsis, the role of PAD2 remains unknown. Here, we report that PAD2 is engaged in sepsis and sepsis-induced acute lung injury in both human patients and mice. Pad2-/- or selective inhibition of PAD2 by a small molecule inhibitor increased survival and improved overall outcomes in m ...[more]