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Shining light on rhodopsin selectivity: How do proteins decide whether to transport H+ or Cl-?


ABSTRACT: The versatile microbial rhodopsin family performs a variety of biological tasks using a highly conserved architecture, making it difficult to understand the mechanistic basis for different functions. Besaw et al. now report structures of a recently discovered cyanobacterial Cl--pumping rhodopsin and its functionally divergent mutant that reveal how these transmembrane proteins create a gradient of activity with subtle changes. These insights are paralleled by a second recent report, which in combination answers long-standing questions about rhodopsin selectivity and will facilitate future engineering efforts.

SUBMITTER: Inoue K 

PROVIDER: S-EPMC7606678 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Shining light on rhodopsin selectivity: How do proteins decide whether to transport H<sup>+</sup> or Cl<sup>-</sup>?

Inoue Keiichi K  

The Journal of biological chemistry 20201001 44


The versatile microbial rhodopsin family performs a variety of biological tasks using a highly conserved architecture, making it difficult to understand the mechanistic basis for different functions. Besaw <i>et al.</i> now report structures of a recently discovered cyanobacterial Cl<sup>-</sup>-pumping rhodopsin and its functionally divergent mutant that reveal how these transmembrane proteins create a gradient of activity with subtle changes. These insights are paralleled by a second recent re  ...[more]

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