Unknown

Dataset Information

0

A retrospective cohort study of low-dose intensity-modulated radiotherapy for unresectable liver metastases.


ABSTRACT: OBJECTIVE:To evaluate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) for the treatment of unresectable liver metastases. METHODS:Twenty-five patients with unresectable liver metastases treated with IMRT were enrolled from January 2003 to September 2016. The median longest diameter of the lesions was 3.3 cm (range, 1.6-16.7 cm). The fraction dose ranged from 2 to 5.2 Gy, with a median total dose of 50 Gy (range, 30-60 Gy). RESULTS:The median follow-up was 9.2 months (range, 2.1-48.8 months). The overall survival rates at 1 and 2 years were 46.4% and 27.4%, respectively. The 1-year local control rate was 69.8%. The 1-year progression-free survival rate was 26.3%. One patient had grade 4 liver dysfunction. One case of grade 4 leukopenia and one case of grade 3 leukopenia occurred, and one case of grade 3 leukopenia and thrombocytopenia was observed. CONCLUSION:IMRT may be a promising and safe treatment for unresectable liver metastases and can be used as a treatment option.

SUBMITTER: Pei S 

PROVIDER: S-EPMC7607147 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

A retrospective cohort study of low-dose intensity-modulated radiotherapy for unresectable liver metastases.

Pei Su S   Chen Kaihua K   Yang Yunli Y   Chen Long L   Zhu Xiaodong X  

The Journal of international medical research 20191228 4


<h4>Objective</h4>To evaluate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) for the treatment of unresectable liver metastases.<h4>Methods</h4>Twenty-five patients with unresectable liver metastases treated with IMRT were enrolled from January 2003 to September 2016. The median longest diameter of the lesions was 3.3 cm (range, 1.6-16.7 cm). The fraction dose ranged from 2 to 5.2 Gy, with a median total dose of 50 Gy (range, 30-60 Gy).<h4>Results</h4>The median follow-up w  ...[more]

Similar Datasets

| S-EPMC9402727 | biostudies-literature
| S-EPMC8714746 | biostudies-literature
| S-EPMC9440238 | biostudies-literature
| S-EPMC7594624 | biostudies-literature
| S-EPMC6043516 | biostudies-literature
| S-EPMC6199734 | biostudies-literature
| S-EPMC10556837 | biostudies-literature
| S-EPMC6020831 | biostudies-literature
| S-EPMC6043750 | biostudies-other
| S-EPMC4642560 | biostudies-other