Ontology highlight
ABSTRACT:
SUBMITTER: Kim K
PROVIDER: S-EPMC7607149 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kim KyeongJin K Yang Wen-Hao WH Jung Youn-Sang YS Cha Jong-Ho JH
BMB reports 20201101 10
T-cell-based cancer immunotherapies, such as immune checkpoint blockers (ICBs) and chimeric antigen receptor (CAR)-Tcells, have significant anti-tumor effects against certain types of cancer, providing a new paradigm for cancer treatment. However, the activity of tumor infiltrating T-cells (TILs) can be effectively neutralized in the tumor microenvironment (TME) of most solid tumors, rich in various immunosuppressive factors and cells. Therefore, to improve the clinical outcomes of established T ...[more]