Genetic factors associated with cancer racial disparity - an integrative study across twenty-one cancer types.

ABSTRACT: It is well known that different racial groups have significantly different incidence and mortality rates for certain cancers. It has been suggested that biological factors play a major role in these cancer racial disparities. Previous studies on the biological factors contributing to cancer racial disparity have generated a very large number of candidate factors, although there is modest agreement among the results of the different studies. Here, we performed an integrative analysis using genomic data of 21 cancer types from TCGA, GTEx, and the 1000 Genomes Project to identify biological factors contributing to racial disparity in cancer. We also built a companion website with additional results for cancer researchers to freely mine. Our study identified genes, gene families, and pathways

SUBMITTER: Li Y 

PROVIDER: S-EPMC7607166 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature