Ontology highlight
ABSTRACT:
SUBMITTER: Uhlig F
PROVIDER: S-EPMC7607502 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Uhlig Friederike F Grundy Luke L Garcia-Caraballo Sonia S Brierley Stuart M SM Foster Simon J SJ Grundy David D
iScience 20201017 11
Despite recently established contributions of the intestinal microbiome to human health and disease, our understanding of bacteria-host communication pathways with regard to the gut-brain axis remains limited. Here we provide evidence that intestinal neurons are able to "sense" bacteria independently of the host immune system. Using supernatants from cultures of the opportunistic pathogen <i>Staphylococcus aureus</i> (<i>S</i>. <i>aureus</i>) we demonstrate the release of mediators with neuromod ...[more]