Ontology highlight
ABSTRACT:
SUBMITTER: Hsiao WY
PROVIDER: S-EPMC7607535 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Hsiao Wen-Yu WY Jung Su Myung SM Tang Yuefeng Y Haley John A JA Li Rui R Li Huawei H Calejman Camila Martinez CM Sanchez-Gurmaches Joan J Hung Chien-Min CM Luciano Amelia K AK DeMambro Victoria V Wellen Kathryn E KE Rosen Clifford J CJ Zhu Lihua Julie LJ Guertin David A DA
Cell reports 20201001 1
Overweight and obesity are associated with type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease and cancer, but all fat is not equal, as storing excess lipid in subcutaneous white adipose tissue (SWAT) is more metabolically favorable than in visceral fat. Here, we uncover a critical role for mTORC2 in setting SWAT lipid handling capacity. We find that subcutaneous white preadipocytes differentiating without the essential mTORC2 subunit Rictor upregulate mature adipocyte mar ...[more]