Serum microRNA as indicators of Wolfram syndrome's progression in neuroimaging studies.

ABSTRACT:

Introduction

Patients with the ultra-rare Wolfram syndrome (WFS) develop insulin-dependent diabetes and progressive neurodegeneration. The aim of the study was to quantify microRNAs (miRNAs) in sera from patients with WFS, correlate their expression with neurological imaging over time and compare miRNA levels with those observed in patients with type 1 diabetes mellitus (T1DM).

Research design and methods

We quantified miRNA expression (Qiagen, Germany) in two groups of patients: with WFS at study entry (n=14) and after 2 years of follow-up and in 15 glycated hemoglobin-matched (p=0.72) patients with T1DM.

Results

We observed dynamic changes in the expression of multiple miRNAs in patients with WFS parallel to disease progression and in comparison to the T1DM patients

SUBMITTER: Zmyslowska A 

PROVIDER: S-EPMC7607591 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature