Ontology highlight
ABSTRACT:
SUBMITTER: Barcellona MN
PROVIDER: S-EPMC7608136 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Barcellona Marcos N MN Speer Julie E JE Fearing Bailey V BV Jing Liufang L Pathak Amit A Gupta Munish C MC Buchowski Jacob M JM Kelly Michael M Setton Lori A LA
Biomaterials 20200422
Cells of the nucleus pulposus have been observed to undergo a shift from their notochordal-like juvenile phenotype to a more fibroblast-like state with age and maturation. It has been demonstrated that culture of degenerative adult human nucleus pulposus cells upon soft (<1 kPa) full length laminin-containing hydrogel substrates promotes increased levels of a panel of markers associated with the juvenile nucleus pulposus cell phenotype. In the current work, we observed an ability to use soft pol ...[more]