Ontology highlight
ABSTRACT:
SUBMITTER: Fang F
PROVIDER: S-EPMC7608799 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Fang Fei F Schwartz Andrea G AG Moore Emily R ER Sup McKenzie E ME Thomopoulos Stavros S
Science advances 20201030 44
The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone. Enthesis pathologies are common, and surgical repair of tendon to bone is plagued by high failure rates. At the root of these failures is a gap in knowledge of how the tendon enthesis is formed and maintained. We tested the hypothesis that the primary cilium is a hub for transducing biophysical and hedgehog (Hh) signals to regulate tendon enthesis formation and adaptation to loading. Primary cilia ...[more]