Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts.
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ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC7608803 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts.
Yang Sujuan S Zhang Ximei X Chen Jingrong J Dang Junlong J Liang Rongzhen R Zeng Donglan D Zhang Huan H Xue Youqiu Y Liu Yan Y Wu Wenbin W Zhao Jun J Wang Julie J Pan Yunfeng Y Xu Hanshi H Sun Bing B Huang Feng F Lu Yan Y Hsueh Willa W Olsen Nancy N Zheng Song Guo SG
Science advances 20201028 44
Aberrant number and/or dysfunction of CD4<sup>+</sup>Foxp3<sup>+</sup> Regulatory T cells (T<sub>regs</sub>) are associated with the pathogenesis of rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural T<sub>regs</sub> (nT<sub>regs</sub>) prefer to accumulate in inflamed joints and transdifferentiate to T<sub>H</sub>17 cells under the stimulation of inflamed synovial fibroblasts (SFs). In this study, we made a head-to-head comparison of both T<sub>reg</sub> s ...[more]
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