Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC7608808 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Fengjiang F Liang Jingxi J Zhang Bing B Gao Yan Y Yang Xiuna X Hu Tianyu T Yang Haitao H Xu Wenqing W Guddat Luke W LW Rao Zihe Z
Science advances 20201030 44
In bacteria, adenosine 5'-triphosphate (ATP)-binding cassette (ABC) importers are essential for the uptake of nutrients including the nonreducing disaccharide trehalose, a metabolite that is crucial for the survival and virulence of several human pathogens including <i>Mycobacterium tuberculosis</i> SugABC is an ABC transporter that translocates trehalose from the periplasmic lipoprotein LpqY into the cytoplasm of mycobacteria. Here, we report four high-resolution cryo-electron microscopy struct ...[more]