Ontology highlight
ABSTRACT:
SUBMITTER: Lolicato M
PROVIDER: S-EPMC7608817 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lolicato Marco M Natale Andrew M AM Abderemane-Ali Fayal F Crottès David D Capponi Sara S Duman Ramona R Wagner Armin A Rosenberg John M JM Grabe Michael M Minor Daniel L DL
Science advances 20201030 44
K<sub>2P</sub> potassium channels regulate cellular excitability using their selectivity filter (C-type) gate. C-type gating mechanisms, best characterized in homotetrameric potassium channels, remain controversial and are attributed to selectivity filter pinching, dilation, or subtle structural changes. The extent to which such mechanisms control C-type gating of innately heterodimeric K<sub>2P</sub>s is unknown. Here, combining K<sub>2P</sub>2.1 (TREK-1) x-ray crystallography in different pota ...[more]