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Reaction of H₂ with mitochondria-relevant metabolites using a multifunctional molecular catalyst.

ABSTRACT: The Krebs cycle is the fuel/energy source for cellular activity and therefore of paramount importance for oxygen-based life. The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH₂, as well as C₄-, C₅-, and C₆-polycarboxylic acids as energy-poor metabolites. These metabolites are biorenewable resources that represent potential sustainable carbon feedstocks, provided that carbon-hydrogen bonds are restored to these molecules. In the present study, these polycarboxylic acids and other mitochondria-relevant metabolites underwent dehydration (alcohol-to-olefin and/or dehydrative cyclization) and reduction (hydrogenation and hydrogenolysis) to diols or triols upon reaction with H₂, catalyzed by sterically confined iridium-bipyridyl complexes. The investigation of these single-metal site catalysts provides valuable molecular insights into the development of molecular technologies for the reduction and dehydration of highly functionalized carbon resources.

SUBMITTER: Yoshioka S

PROVIDER: S-EPMC7608823 | biostudies-literature |

REPOSITORIES: biostudies-literature

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