Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding.

ABSTRACT: Spatial navigation requires landmark coding from two perspectives, relying on viewpoint-invariant and self-referenced representations. The brain encodes information within each reference frame but their interactions and functional dependency remains unclear. Here we investigate the relationship between neurons in the rat's retrosplenial cortex (RSC) and entorhinal cortex (MEC) that increase firing near boundaries of space. Border cells in RSC specifically encode walls, but not objects, and are sensitive to the animal's direction to nearby borders. These egocentric representations are generated independent of visual or whisker sensation but are affected by inputs from MEC that contains allocentric spatial cells. Pharmaco- and optogenetic inhibition of MEC led to a disruption of border codin

SUBMITTER: van Wijngaarden JB 

PROVIDER: S-EPMC7609058 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature