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Ecotoxicity and genotoxicity assessment of losartan after UV/H₂O₂ and UVC/photolysis treatments.

ABSTRACT: Losartan potassium (LOS) is one of the most antihypertensives used in the world, and its presence in environmental matrices can cause impacts to biota. In this study, the ecotoxicity and genotoxicity of LOS was assessed before and after treatment by UVC/photolysis and UV/H₂O₂. The photodegradations were carried out at LOS solutions (2.5 mg L^-1; 4.6 ?M) for 30, 60, 90, 120, 240, and 480 min of treatment. For chromatographic analysis, the samples were submitted to solid-phase extraction (SPE) and analyzed by HPLC-DAD. Ecotoxicity bioassays were conducted using Daphnia magna (acute) and Desmodesmus subspicatus (chronic) for all the degradation times. To evaluate the genotoxicity, the comet assay was performed with a D. magna whole organism cell suspension applying the alkaline gel electrophoresis technique. For both process, the degradation rate was over 99% at 30 min, which reduced the acute toxicity of LOS to D. magna. In addition, only the sample treated at 240 min by UV/H₂O₂ showed significant chronic and acute toxicity. However, the genotoxicity effect was observed for samples treated LOS before treatment and at 480 min by UV/H₂O₂. Therefore, even reaching high LOS degradation rates, for both processes, the bioassays demonstrated the importance of ecotoxicological analyses by AOPs treatment.

SUBMITTER: Adams E

PROVIDER: S-EPMC7609376 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Ecotoxicity and genotoxicity assessment of losartan after UV/H2O2 and UVC/photolysis treatments.

Adams Eliane E Neves Bruno B BB Prola Liziê D T LDT de Liz Marcus V MV Martins Lucia R R LRR Ramsdorf Wanessa A WA de Freitas Adriane M AM

Environmental science and pollution research international 20201104 19

Losartan potassium (LOS) is one of the most antihypertensives used in the world, and its presence in environmental matrices can cause impacts to biota. In this study, the ecotoxicity and genotoxicity of LOS was assessed before and after treatment by UVC/photolysis and UV/H2O2. The photodegradations were carried out at LOS solutions (2.5 mg L-1; 4.6 μM) for 30, 60, 90, 120, 240, and 480 min of treatment. For chromatographic analysis, the samples were submitted to ...[more]

PMID: 33145733

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Project description:AtGenExpress: A multinational coordinated effort to uncover the transcriptome of the multicellular model organism Arabidopsis thaliana. The activity of genes and their encoded products can be regulated in several ways, but transcription is the primary level, since all other modes of regulation (RNA splicing, RNA and protein stability, etc.) are dependent on a gene being transcribed in the first place. The importance of transcriptional regulation has been underscored by the recent flood of global expression analyses, which have confirmed that transcriptional co-regulation of genes that act together is the norm, not the exception. Moreover, many studies suggest that evolutionary change is driven in large part by modifications of transcriptional programs. An essential first step toward deciphering the transcriptional code is to determine the expression pattern of all genes. With this goal in mind, an international effort to develop a gene expression atlas of Arabidopsis has been underway since fall 2003. This project, dubbed AtGenExpress, is funded by the DFG, and will provide the Arabidopsis community with access to a large set of Affymetrix microarray data. As part of this collaboration, we have generated expression data from 80 biologicaly different samples in triplicate. Seeds of Arabidopsis thaliana Wild Type (col-0) were sown on rafts in Magenta boxes containing MS-Agar-media. After 2 days in the cold room (4°C, dark) the boxes were transferred to the long day chamber. Long day conditions were 16/8 hrs light/dark, 24°C, 50% humidity and 150 µEinstein/cm2 sec light intensity. At day 11 the rafts were transferred in Magenta boxes containing MS-liquid-media. At day 16 stress treatment started at 3 hrs of light period; samples taken at 0.5, 1, 3, 6, 12, 24 h after treatment (in selected indicated cases 0.25h and 4.0h too), control samples include 0h; roots and shoots were prepared separately; all treatments and preparations were done on the same batch of seedlings in one place (Lab J.Kudla/Ulm, Germany) by coworkers from the indicated groups. Experimenter name = Jakub Horak , Klaus Harter Experimenter institute = AtGenExpress Keywords: growth_condition_design; time_series_design; stimulus_or_stress_design

Dataset Information

Ecotoxicity and genotoxicity assessment of losartan after UV/H₂O₂ and UVC/photolysis treatments.

Publications

Ecotoxicity and genotoxicity assessment of losartan after UV/H<sub>2</sub>O<sub>2</sub> and UVC/photolysis treatments.

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