Ontology highlight
ABSTRACT:
SUBMITTER: Cui X
PROVIDER: S-EPMC7609463 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cui Xiangling X Zhou Rui R Huang Chenchao C Zhang Rongyu R Wang Jing J Zhang Yongxin Y Ding Jiwei J Li Xiaoyu X Zhou Jinming J Cen Shan S
Frontiers in pharmacology 20201021
Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral heterodimeric serine protease NS2B-NS3 plays an essential role in ZIKV maturation and replication, thus becoming a promising target in anti-ZIKV therapy. Herein, we developed a fluorescence-based screening assay to search for inhibitors targetin ...[more]