Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC7610308 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gao Yuan Y Li Xiaoju X Zeng Cheng C Liu Chenlin C Hao Qiang Q Li Weina W Zhang Kuo K Zhang Wangqian W Wang Shuning S Zhao Huadong H Fan Dong D Li Meng M Zhang Yingqi Y Zhang Wei W Zhang Cun C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200924 21
Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)-positive breast cancer. However, many patients still develop resistance to tamoxifen in association with metastatic recurrence, which presents a tremendous clinical challenge. To better understand tamoxifen resistance from the perspective of the tumor microenvironment, the whole microenvironment landscape is charted by single-cell RNA sequencing and a new cancer-associated fibroblast (CAF) subset, CD63<sup>+</sup> CAFs, ...[more]