Robust spike timing in an excitable cell with delayed feedback.
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ABSTRACT:
SUBMITTER: Wedgwood KCA
PROVIDER: S-EPMC7610669 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Robust spike timing in an excitable cell with delayed feedback.
Wedgwood Kyle C A KCA Słowiński Piotr P Manson James J Tsaneva-Atanasova Krasimira K Krauskopf Bernd B
Journal of the Royal Society, Interface 20210414 177
The initiation and regeneration of pulsatile activity is a ubiquitous feature observed in excitable systems with delayed feedback. Here, we demonstrate this phenomenon in a real biological cell. We establish a critical role of the delay resulting from the finite propagation speed of electrical impulses in the emergence of persistent multiple-spike patterns. We predict the coexistence of a number of such patterns in a mathematical model and use a biological cell subject to dynamic clamp to confir ...[more]
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