Ontology highlight
ABSTRACT:
SUBMITTER: Muriuki JM
PROVIDER: S-EPMC7610676 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Muriuki John Muthii JM Mentzer Alexander J AJ Mitchell Ruth R Webb Emily L EL Etyang Anthony O AO Kyobutungi Catherine C Morovat Alireza A Kimita Wandia W Ndungu Francis M FM Macharia Alex W AW Ngetsa Caroline J CJ Makale Johnstone J Lule Swaib A SA Musani Solomon K SK Raffield Laura M LM Cutland Clare L CL Sirima Sodiomon B SB Diarra Amidou A Tiono Alfred B AB Fried Michal M Gwamaka Moses M Adu-Afarwuah Seth S Wirth James P JP Wegmüller Rita R Madhi Shabir A SA Snow Robert W RW Hill Adrian V S AVS Rockett Kirk A KA Sandhu Manjinder S MS Kwiatkowski Dominic P DP Prentice Andrew M AM Byrd Kendra A KA Ndjebayi Alex A Stewart Christine P CP Engle-Stone Reina R Green Tim J TJ Karakochuk Crystal D CD Suchdev Parminder S PS Bejon Philip P Duffy Patrick E PE Davey Smith George G Elliott Alison M AM Williams Thomas N TN Atkinson Sarah H SH
Nature medicine 20210222 4
Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID<sup>1</sup>. To test the hypothesis that malaria might cause ID, we used sickle cell trait (HbAS, rs334 ), a genetic variant that confers specific protection against malaria<sup>2</sup>, as an instrumental variable in Mendelian randomization analyses. HbAS was associated with a 30% reduction in ID a ...[more]