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Enteric neurons increase maternal food intake during reproduction.

ABSTRACT: Reproduction induces increased food intake across females of many animal species^1-4, providing a physiologically relevant paradigm for the exploration of appetite regulation. Here, by examining the diversity of enteric neurons in Drosophila melanogaster, we identify a key role for gut-innervating neurons with sex- and reproductive state-specific activity in sustaining the increased food intake of mothers during reproduction. Steroid and enteroendocrine hormones functionally remodel these neurons, which leads to the release of their neuropeptide onto the muscles of the crop-a stomach-like organ-after mating. Neuropeptide release changes the dynamics of crop enlargement, resulting in increased food intake, and preventing the post-mating remodelling of enteric neurons reduces both reproductive hyperphagia and reproductive fitness. The plasticity of enteric neurons is therefore key to reproductive success. Our findings provide a mechanism to attain the positive energy balance that sustains gestation, dysregulation of which could contribute to infertility or weight gain.

SUBMITTER: Hadjieconomou D

PROVIDER: S-EPMC7610780 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

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mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin.

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2013-04-09 | E-GEOD-45858 | biostudies-arrayexpress

GFRAL-expressing Neurons Suppress Food Intake via Aversive Pathways

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Heparin Increases Food Intake through AgRP Neurons.

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| S-EPMC6310124 | biostudies-literature

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FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.

2013-04-09 | GSE45858 | GEO

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Dnmt1/3a deletion in prefrontal cortical neurons reduces palatable food intake

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