Ontology highlight
ABSTRACT:
SUBMITTER: Perino A
PROVIDER: S-EPMC7610881 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Perino Alessia A Velázquez-Villegas Laura A LA Bresciani Nadia N Sun Yu Y Huang Qingyao Q Fénelon Valérie S VS Castellanos-Jankiewicz Ashley A Zizzari Philippe P Bruschetta Giuseppe G Jin Sungho S Baleisyte Aiste A Gioiello Antimo A Pellicciari Roberto R Ivanisevic Julijana J Schneider Bernard L BL Diano Sabrina S Cota Daniela D Schoonjans Kristina K
Nature metabolism 20210524 5
Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain<sup>1</sup>, yet their physiological role in the central nervous system is still largely unknown. Here we show that postprandial BAs can reach the brain and activate a negative-feedback loop controlling satiety in response to physiological feeding via TGR5, a G-protein-coupled receptor activated by multipl ...[more]