Ontology highlight
ABSTRACT:
SUBMITTER: Tichy EM
PROVIDER: S-EPMC7610886 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Tichy Evelyn M EM Hardwick Steven W SW Luisi Ben F BF Salmond George P C GPC
Acta crystallographica. Section D, Structural biology 20170622 Pt 7
The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance ...[more]