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1.8 A resolution crystal structure of the carbapenem intrinsic resistance protein CarF.


ABSTRACT: The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.

SUBMITTER: Tichy EM 

PROVIDER: S-EPMC7610886 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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1.8 Å resolution crystal structure of the carbapenem intrinsic resistance protein CarF.

Tichy Evelyn M EM   Hardwick Steven W SW   Luisi Ben F BF   Salmond George P C GPC  

Acta crystallographica. Section D, Structural biology 20170622 Pt 7


The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance  ...[more]

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