A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images.
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ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC7611049 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The COVID-19 pandemic is causing a major outbreak in more than 150 countries around the world, having a severe impact on the health and life of many people globally. One of the crucial step in fighting COVID-19 is the ability to detect the infected patients early enough, and put them under special care. Detecting this disease from radiography and radiology images is perhaps one of the fastest ways to diagnose the patients. Some of the early studies showed specific abnormalities in the chest radiograms of patients infected with COVID-19. Inspired by earlier works, we study the application of deep learning models to detect COVID-19 patients from their chest radiography images. We first prepare a dataset of 5000 Chest X-rays from the publicly available datasets. Images exhibiting COVID-19 disease presence were identified by board-certified radiologist. Transfer learning on a subset of 2000 radiograms was used to train four popular convolutional neural networks, including ResNet18, ResNet50, SqueezeNet, and DenseNet-121, to identify COVID-19 disease in the analyzed chest X-ray images. We evaluated these models on the remaining 3000 images, and most of these networks achieved a sensitivity rate of 98% ( ± 3%), while having a specificity rate of around 90%. Besides sensitivity and specificity rates, we also present the receiver operating characteristic (ROC) curve, precision-recall curve, average prediction, and confusion matrix of each model. We also used a technique to generate heatmaps of lung regions potentially infected by COVID-19 and show that the generated heatmaps contain most of the infected areas annotated by our board certified radiologist. While the achieved performance is very encouraging, further analysis is required on a larger set of COVID-19 images, to have a more reliable estimation of accuracy rates. The dataset, model implementations (in PyTorch), and evaluations, are all made publicly available for research community at https://github.com/shervinmin/DeepCovid.git.
| S-EPMC7372265 | biostudies-literature
Project description:Chest X-ray (CXR) is widely used to diagnose conditions affecting the chest, its contents, and its nearby structures. In this study, we used a private data set containing 1630 CXR images with disease labels; most of the images were disease-free, but the others contained multiple sites of abnormalities. Here, we used deep convolutional neural network (CNN) models to extract feature representations and to identify possible diseases in these images. We also used transfer learning combined with large open-source image data sets to resolve the problems of insufficient training data and optimize the classification model. The effects of different approaches of reusing pretrained weights (model finetuning and layer transfer), source data sets of different sizes and similarity levels to the target data (ImageNet, ChestX-ray, and CheXpert), methods integrating source data sets into transfer learning (initiating, concatenating, and co-training), and backbone CNN models (ResNet50 and DenseNet121) on transfer learning were also assessed. The results demonstrated that transfer learning applied with the model finetuning approach typically afforded better prediction models. When only one source data set was adopted, ChestX-ray performed better than CheXpert; however, after ImageNet initials were attached, CheXpert performed better. ResNet50 performed better in initiating transfer learning, whereas DenseNet121 performed better in concatenating and co-training transfer learning. Transfer learning with multiple source data sets was preferable to that with a source data set. Overall, transfer learning can further enhance prediction capabilities and reduce computing costs for CXR images.
| S-EPMC9222116 | biostudies-literature
Project description:A newly emerged coronavirus (COVID-19) seriously threatens human life and health worldwide. In coping and fighting against COVID-19, the most critical step is to effectively screen and diagnose infected patients. Among them, chest X-ray imaging technology is a valuable imaging diagnosis method. The use of computer-aided diagnosis to screen X-ray images of COVID-19 cases can provide experts with auxiliary diagnosis suggestions, which can reduce the burden of experts to a certain extent. In this study, we first used conventional transfer learning methods, using five pre-trained deep learning models, which the Xception model showed a relatively ideal effect, and the diagnostic accuracy reached 96.75%. In order to further improve the diagnostic accuracy, we propose an efficient diagnostic method that uses a combination of deep features and machine learning classification. It implements an end-to-end diagnostic model. The proposed method was tested on two datasets and performed exceptionally well on both of them. We first evaluated the model on 1102 chest X-ray images. The experimental results show that the diagnostic accuracy of Xception + SVM is as high as 99.33%. Compared with the baseline Xception model, the diagnostic accuracy is improved by 2.58%. The sensitivity, specificity and AUC of this model reached 99.27%, 99.38% and 99.32%, respectively. To further illustrate the robustness of our method, we also tested our proposed model on another dataset. Finally also achieved good results. Compared with related research, our proposed method has higher classification accuracy and efficient diagnostic performance. Overall, the proposed method substantially advances the current radiology based methodology, it can be very helpful tool for clinical practitioners and radiologists to aid them in diagnosis and follow-up of COVID-19 cases.
| S-EPMC7671547 | biostudies-literature
Project description:Covid-19 has become a deadly pandemic claiming more than three million lives worldwide. SARS-CoV-2 causes distinct pathomorphological alterations in the respiratory system, thereby acting as a biomarker to aid its diagnosis. A multimodal framework (Ai-CovScan) for Covid-19 detection using breathing sounds, chest X-ray (CXR) images, and rapid antigen test (RAnT) is proposed. Transfer Learning approach using existing deep-learning Convolutional Neural Network (CNN) based on Inception-v3 is combined with Multi-Layered Perceptron (MLP) to develop the CovScanNet model for reducing false-negatives. This model reports a preliminary accuracy of 80% for the breathing sound analysis, and 99.66% Covid-19 detection accuracy for the curated CXR image dataset. Based on Ai-CovScan, a smartphone app is conceptualised as a mass-deployable screening tool, which could alter the course of this pandemic. This app's deployment could minimise the number of people accessing the limited and expensive confirmatory tests, thereby reducing the burden on the severely stressed healthcare infrastructure.
| S-EPMC8149173 | biostudies-literature
Project description:BackgroundNowadays doctors and radiologists are overwhelmed with a huge amount of work. This led to the effort to design different Computer-Aided Diagnosis systems (CAD system), with the aim of accomplishing a faster and more accurate diagnosis. The current development of deep learning is a big opportunity for the development of new CADs. In this paper, we propose a novel architecture for a convolutional neural network (CNN) ensemble for classifying chest X-ray (CRX) images into four classes: viral Pneumonia, Tuberculosis, COVID-19, and Healthy. Although Computed tomography (CT) is the best way to detect and diagnoses pulmonary issues, CT is more expensive than CRX. Furthermore, CRX is commonly the first step in the diagnosis, so it's very important to be accurate in the early stages of diagnosis and treatment.ResultsWe applied the transfer learning technique and data augmentation to all CNNs for obtaining better performance. We have designed and evaluated two different CNN-ensembles: Stacking and Voting. This system is ready to be applied in a CAD system to automated diagnosis such a second or previous opinion before the doctors or radiology's. Our results show a great improvement, 99% accuracy of the Stacking Ensemble and 98% of accuracy for the the Voting Ensemble.ConclusionsTo minimize missclassifications, we included six different base CNN models in our architecture (VGG16, VGG19, InceptionV3, ResNet101V2, DenseNet121 and CheXnet) and it could be extended to any number as well as we expect extend the number of diseases to detected. The proposed method has been validated using a large dataset created by mixing several public datasets with different image sizes and quality. As we demonstrate in the evaluation carried out, we reach better results and generalization compared with previous works. In addition, we make a first approach to explainable deep learning with the objective of providing professionals more information that may be valuable when evaluating CRXs.
| S-EPMC9568999 | biostudies-literature
Project description:Over the past decade, the use of deep learning has been widely increasing in the medical image diagnosis field. Deep learning-based methods' (DLMs) performance strongly relies on training data. Therefore, researchers often focus on collecting as much data as possible from different medical facilities or developing approaches to avoid the impact of inter-category imbalance (ICI), which means a difference in data quantity among categories. However, due to the ICI within each medical facility, medical data are often isolated and acquired in different settings among medical facilities, known as the issue of intra-source imbalance (ISI) characteristic. This imbalance also impacts the performance of DLMs but receives negligible attention. In this study, we study the impact of the ISI on DLMs by comparison of the version of a deep learning model that was trained separately by an intra-source imbalanced chest X-ray (CXR) dataset and an intra-source balanced CXR dataset for COVID-19 diagnosis. The finding is that using the intra-source imbalanced dataset causes a serious training bias, although the dataset has a good inter-category balance. In contrast, the deep learning model performed a reliable diagnosis when trained on the intra-source balanced dataset. Therefore, our study reports clear evidence that the intra-source balance is vital for training data to minimize the risk of poor performance of DLMs.
| S-EPMC10624834 | biostudies-literature
Project description:The lethal novel coronavirus disease 2019 (COVID-19) pandemic is affecting the health of the global population severely, and a huge number of people may have to be screened in the future. There is a need for effective and reliable systems that perform automatic detection and mass screening of COVID-19 as a quick alternative diagnostic option to control its spread. A robust deep learning-based system is proposed to detect the COVID-19 using chest X-ray images. Infected patient's chest X-ray images reveal numerous opacities (denser, confluent, and more profuse) in comparison to healthy lungs images which are used by a deep learning algorithm to generate a model to facilitate an accurate diagnostics for multi-class classification (COVID vs. normal vs. bacterial pneumonia vs. viral pneumonia) and binary classification (COVID-19 vs. non-COVID). COVID-19 positive images have been used for training and model performance assessment from several hospitals of India and also from countries like Australia, Belgium, Canada, China, Egypt, Germany, Iran, Israel, Italy, Korea, Spain, Taiwan, USA, and Vietnam. The data were divided into training, validation and test sets. The average test accuracy of 97.11 ± 2.71% was achieved for multi-class (COVID vs. normal vs. pneumonia) and 99.81% for binary classification (COVID-19 vs. non-COVID). The proposed model performs rapid disease detection in 0.137 s per image in a system equipped with a GPU and can reduce the workload of radiologists by classifying thousands of images on a single click to generate a probabilistic report in real-time.
| S-EPMC7837255 | biostudies-literature
Project description:BackgroundStress echocardiography is an emerging tool used to detect exercise-induced pulmonary hypertension (EIPH). However, facilities that can perform stress echocardiography are limited by issues such as cost and equipment.ObjectiveWe evaluated the usefulness of a deep learning (DL) approach based on a chest X-ray (CXR) to predict EIPH in 6-min walk stress echocardiography.MethodsThe study enrolled 142 patients with scleroderma or mixed connective tissue disease with scleroderma features who performed a 6-min walk stress echocardiographic test. EIPH was defined by abnormal cardiac output (CO) responses that involved an increase in mean pulmonary artery pressure (mPAP). We used the previously developed AI model to predict PH and calculated PH probability in this cohort.ResultsEIPH defined as ΔmPAP/ΔCO >3.3 and exercise mPAP >25 mmHg was observed in 52 patients, while non-EIPH was observed in 90 patients. The patients with EIPH had a higher mPAP at rest than those without EIPH. The probability of PH based on the DL model was significantly higher in patients with EIPH than in those without EIPH. Multivariate analysis showed that gender, mean PAP at rest, and the probability of PH based on the DL model were independent predictors of EIPH. A model based on baseline parameters (age, gender, and mPAP at rest) was improved by adding the probability of PH predicted by the DL model (AUC: from 0.65 to 0.74; p = 0.046).ConclusionApplying the DL model based on a CXR may have a potential for detection of EIPH in the clinical setting.
| S-EPMC9240342 | biostudies-literature
Project description:Chest X-ray (CXR) imaging is a standard and crucial examination method used for suspected cases of coronavirus disease (COVID-19). In profoundly affected or limited resource areas, CXR imaging is preferable owing to its availability, low cost, and rapid results. However, given the rapidly spreading nature of COVID-19, such tests could limit the efficiency of pandemic control and prevention. In response to this issue, artificial intelligence methods such as deep learning are promising options for automatic diagnosis because they have achieved state-of-the-art performance in the analysis of visual information and a wide range of medical images. This paper reviews and critically assesses the preprint and published reports between March and May 2020 for the diagnosis of COVID-19 via CXR images using convolutional neural networks and other deep learning architectures. Despite the encouraging results, there is an urgent need for public, comprehensive, and diverse datasets. Further investigations in terms of explainable and justifiable decisions are also required for more robust, transparent, and accurate predictions.
| S-EPMC8545235 | biostudies-literature
Project description:Even after scavenging the existence of mankind for the past year, the wrath of CoVID-19 is yet to die down. Countries like India are still getting haunted by the devastating conundrum, with coronavirus ripping through its citizens in the concurrent second wave. The surge of cases has prompted rapid intervention, with medical authorities pushing it to the limit to curve a roadblock to its aggressive growth. But, even after effortless work, human intervention remains slow and insufficient. Furthermore, relevant testing methodologies have shown weakness while detecting threats, with the recent growth of post-Covid complexities, thereby leaving a painful mark. This as such created a major requirement for technological advancements, which can cater to the mass. The growth of computational prowess in the past decade made the field of Deep Learning a major contributor in curving out algorithms to solve this. Adding to the excellent foundation of Deep Learning, this paper, proposes a novel CoWarriorNet model for rapid detection of CoVID-19, via chest X-ray images, which adds in an extra layer of precision and confirmation in the detection of cases in both pre-Covid and post-Covid conditions. The proposed classification model curves out an excellent accuracy of 97.8%, with the major eye-candy being the sensitivity rate of 0.99 when detecting CoVID-19 cases. This model introduces a new concept of Alpha Trimmed Average Pooling, which along with the novel architecture adds a subtle touch to its high efficiency, thereby giving a much-needed solution to the medical experts. The two-mouthed architecture provides the added benefit of a confidence score, deducing human aid in case of discrepancy.Supplementary informationThe online version contains supplementary material available at 10.1007/s00354-021-00143-1.
| S-EPMC8639408 | biostudies-literature