Ontology highlight
ABSTRACT:
SUBMITTER: Geng J
PROVIDER: S-EPMC7611443 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Geng Jin J Zhang Yichuan Y Gao Quan Q Neumann Kevin K Dong Hua H Porter Hamish H Potter Mark M Ren Hua H Argyle David D Bradley Mark M
Nature chemistry 20210610 8
Chemotherapy is a powerful tool in the armoury against cancer, but it is fraught with problems due to its global systemic toxicity. Here we report the proof of concept of a chemistry-based strategy, whereby gamma/X-ray irradiation mediates the activation of a cancer prodrug, thereby enabling simultaneous chemo-radiotherapy with radiotherapy locally activating a prodrug. In an initial demonstration, we show the activation of a fluorescent probe using this approach. Expanding on this, we show how ...[more]