Ontology highlight
ABSTRACT:
SUBMITTER: Raymond MH
PROVIDER: S-EPMC7612538 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Raymond Michael H MH Davidson Andrew J AJ Shen Yi Y Tudor Daniel R DR Lucas Christopher D CD Morioka Sho S Perry Justin S A JSA Krapivkina Julia J Perrais David D Schumacher Linus J LJ Campbell Robert E RE Wood Will W Ravichandran Kodi S KS
Science (New York, N.Y.) 20220310 6585
Apoptosis of cells and their subsequent removal through efferocytosis occurs in nearly all tissues during development, homeostasis, and disease. However, it has been difficult to track cell death and subsequent corpse removal in vivo. We developed a genetically encoded fluorescent reporter, CharON (Caspase and pH Activated Reporter, Fluorescence ON), that could track emerging apoptotic cells and their efferocytic clearance by phagocytes. Using <i>Drosophila</i> expressing CharON, we uncovered mu ...[more]