Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children.

ABSTRACT:

Background

The tryptophan-kynurenine (KYN) pathway is linked to obesity-related systemic inflammation and metabolic health. The pathway generates multiple metabolites, with little available data on their relationships to early markers of increased metabolic disease risk in children. The aim of this study was to examine the association of multiple KYN pathway metabolites with metabolic risk markers in prepubertal Asian children.

Methods

Fasting plasma concentrations of KYN pathway metabolites were measured using liquid chromatography-tandem mass spectrometry in 8-year-old children (n = 552) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring cohort study. The child's weight and height were used to ascertain overweight and obesity usi

SUBMITTER: Tan KM 

PROVIDER: S-EPMC7612806 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature