Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study.

ABSTRACT:

Objective

Polycystic ovary syndrome (PCOS) has been associated with an increased risk of coronary artery disease (CAD). However, it remains uncertain whether this increased risk is the result of PCOS per se or, alternatively, is explained by obesity, a common feature of PCOS. The aim of this study was to assess the causal association between PCOS and CAD and the role of obesity herein.

Design and methods

We conducted two-sample Mendelian randomisation analyses in large-scale, female-specific datasets to study the association between genetically predicted (1) risk of PCOS and risk of CAD, (2) body mass index (BMI) and risk of PCOS and (3) BMI and risk of CAD. Primary analyses were conducted with the inverse-variance weighted (IVW) method. Simple median, penalized weighted med

SUBMITTER: Simons PIHG 

PROVIDER: S-EPMC7612926 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature