Ontology highlight
ABSTRACT:
SUBMITTER: Schmacke NA
PROVIDER: S-EPMC7614333 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Schmacke Niklas A NA O'Duill Fionan F Gaidt Moritz M MM Szymanska Inga I Kamper Julia M JM Schmid-Burgk Jonathan L JL Mädler Sophia C SC Mackens-Kiani Timur T Kozaki Tatsuya T Chauhan Dhruv D Nagl Dennis D Stafford Che A CA Harz Hartmann H Fröhlich Adrian L AL Pinci Francesca F Ginhoux Florent F Beckmann Roland R Mann Matthias M Leonhardt Heinrich H Hornung Veit V
Immunity 20221115 12
The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the context of sterile inflammatory conditions. NLRP3 activity is governed by two independent signals: the first signal primes NLRP3, rendering it responsive to the second signal, which then triggers inflammasome formation. Our understanding of how NLRP3 priming contributes to inflammasome activation remains limited. Here, we show that IKKβ, a kinase activated during priming, induces recruitment of NLRP3 to phosph ...[more]