Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC7640883 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Chen Bin B Longhini Andrew P AP Nußbaumer Felix F Kreutz Christoph C Dinman Jonathan D JD Dayie T Kwaku TK
Chemistry (Weinheim an der Bergstrasse, Germany) 20180325 21
Conformational dynamics of RNA molecules play a critical role in governing their biological functions. Measurements of RNA dynamic behavior sheds important light on sites that interact with their binding partners or cellular stimulators. However, such measurements using solution-state NMR are difficult for large RNA molecules (>70 nt; nt=nucleotides) owing to severe spectral overlap, homonuclear <sup>13</sup> C scalar couplings, and line broadening. Herein, a strategic combination of solid-phase ...[more]