Unknown

Dataset Information

0

Targeting Proteases for Treating COVID-19.


ABSTRACT: The unprecedented pandemic of coronavirus disease 2019 (COVID-19) demands effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The infection of SARS-CoV-2 critically depends on diverse viral or host proteases, which mediate viral entry, viral protein maturation, as well as the pathogenesis of the viral infection. Endogenous and exogenous agents targeting for proteases have been proved to be effective toward a variety of viral infections ranging from HIV to influenza virus, suggesting protease inhibitors as a promising antiviral treatment for COVID-19. In this Review, we discuss how host and viral proteases participated in the pathogenesis of COVID-19 as well as the prospects and ongoing clinical trials of protease inhibitors as treatments.

SUBMITTER: Luan B 

PROVIDER: S-EPMC7640965 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Targeting Proteases for Treating COVID-19.

Luan Binquan B   Huynh Tien T   Cheng Xuemei X   Lan Ganhui G   Wang Hao-Ran HR  

Journal of proteome research 20201022 11


The unprecedented pandemic of coronavirus disease 2019 (COVID-19) demands effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The infection of SARS-CoV-2 critically depends on diverse viral or host proteases, which mediate viral entry, viral protein maturation, as well as the pathogenesis of the viral infection. Endogenous and exogenous agents targeting for proteases have been proved to be effective toward a variety of viral infections ranging from HIV  ...[more]

Similar Datasets

| S-EPMC8850931 | biostudies-literature
| S-EPMC8014870 | biostudies-literature
| S-EPMC7901237 | biostudies-literature
| S-EPMC10840071 | biostudies-literature
| S-EPMC7232130 | biostudies-literature
| S-BSST563 | biostudies-other
| S-EPMC7688049 | biostudies-literature
| S-EPMC8551562 | biostudies-literature
| S-EPMC9215332 | biostudies-literature
| S-EPMC8406455 | biostudies-literature