Ontology highlight
ABSTRACT:
SUBMITTER: Mandala VS
PROVIDER: S-EPMC7641042 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mandala Venkata S VS Loftis Alexander R AR Shcherbakov Alexander A AA Pentelute Bradley L BL Hong Mei M
Nature structural & molecular biology 20200203 2
The influenza B M2 (BM2) proton channel is activated by acidic pH to mediate virus uncoating. Unlike influenza A M2 (AM2), which conducts protons with strong inward rectification, BM2 conducts protons both inward and outward. Here we report 1.4- and 1.5-Å solid-state NMR structures of the transmembrane domain of the closed and open BM2 channels in a phospholipid environment. Upon activation, the transmembrane helices increase the tilt angle by 6° and the average pore diameter enlarges by 2.1 Å. ...[more]