Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.

ABSTRACT:

Background

Although immunomodulatory effects of anesthetics have been increasingly recognized, their underlying molecular mechanisms are not completely understood. Toll-like receptors (TLRs) are one of the major receptors to recognize invading pathogens and danger signals from damaged host tissues to initiate immune responses. Among the TLR family, TLR2 and TLR4 recognize a wide range of ligands and are considered to be important players in perioperative pathophysiology. Based on our recent finding that volatile anesthetics modulate TLR4 function, we tested our hypothesis that they would also modulate TLR2 function.

Methods

The effect of anesthetics isoflurane, sevoflurane, propofol, and dexmedetomidine on TLR2 activation was examined by reporter assays. An anesthetic that a

SUBMITTER: Mitsui Y 

PROVIDER: S-EPMC7641046 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature