Ontology highlight
ABSTRACT:
SUBMITTER: Tornai D
PROVIDER: S-EPMC7641578 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Clinical and molecular hepatology 20200928 4
Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver disease scores >20, and nonspecific symptoms that are caused by underlying inflammation, hepatocyte injury, and impaired intestinal barrier function. Compromised immune defense in AH contributes to infections, sepsis and organ failure. To date, corticosteroids are the only recommended treatment for severe AH, ...[more]