Ontology highlight
ABSTRACT:
SUBMITTER: Yao J
PROVIDER: S-EPMC7641770 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20201101 19
The two-gene module HEPN/MNT is predicted to be the most abundant toxin/antitoxin (TA) system in prokaryotes. However, its physiological function and neutralization mechanism remains obscure. Here, we discovered that the MntA antitoxin (MNT-domain protein) acts as an adenylyltransferase and chemically modifies the HepT toxin (HEPN-domain protein) to block its toxicity as an RNase. Biochemical and structural studies revealed that MntA mediates the transfer of three AMPs to a tyrosine residue next ...[more]