Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers.
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ABSTRACT:
SUBMITTER: Dalbeth N
PROVIDER: S-EPMC7641836 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers.
Dalbeth Nicola N Allan Jordyn J Gamble Gregory D GD Horne Anne A Woodward Owen M OM Stamp Lisa K LK Merriman Tony R TR
Arthritis research & therapy 20201104 1
<h4>Background</h4>High body mass index (BMI) is strongly associated with hyperuricaemia. It is unknown whether overweight and obesity influences serum urate primarily through increased urate production or reduced renal clearance of uric acid. The aim of this study was to determine the influence of BMI on the response to inosine, a purine nucleoside that functions as an intermediate in the purine salvage and degradation pathways.<h4>Methods</h4>Following an overnight fast, 100 healthy participan ...[more]
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