Withdrawal of medications leads to worsening of OGTT parameters in youth with impaired glucose tolerance or recently-diagnosed type 2 diabetes.

ABSTRACT:

Background

The RISE Pediatric Medication Study compared strategies for preserving β-cell function, including a 9-month follow-up after treatment withdrawal to test treatment effect durability.

Objective

Evaluate OGTT measures of glucose and β-cell response through 12 months of intervention and 9 months of medication washout.

Participants

Youth (n = 91) aged 10 to 19 years with BMI ≥85th percentile and impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes (T2D).

Methods

A multicenter randomized clinical trial comparing insulin glargine for 3 months followed by metformin for 9 months (G→Met) or metformin alone (Met) for 12 months. We report within-group changes from baseline to end of medication intervention (M12), baseline to 9 months post-medic

SUBMITTER: Hannon TS 

PROVIDER: S-EPMC7642167 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature