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Organoiridium-quinone conjugates for facile hydrogen peroxide generation.

ABSTRACT: An organoiridium complex bearing a quinone moiety was shown to significantly accelerate the rate of H₂O₂ formation in the presence of air and sodium formate at low catalyst concentrations. This reaction is proposed to operate through a synergistic mechanism involving transfer hydrogenation catalysis and radical chemistry. Our bifunctional iridium complex could potentially be used in anti-cancer chemotherapy or other applications requiring rapid generation of reactive oxygen species.

SUBMITTER: Nguyen HTH

PROVIDER: S-EPMC7642182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Organoiridium-quinone conjugates for facile hydrogen peroxide generation.

Nguyen Huong T H HTH Do Loi H LH

Chemical communications (Cambridge, England) 20201009 87

An organoiridium complex bearing a quinone moiety was shown to significantly accelerate the rate of H<sub>2</sub>O<sub>2</sub> formation in the presence of air and sodium formate at low catalyst concentrations. This reaction is proposed to operate through a synergistic mechanism involving transfer hydrogenation catalysis and radical chemistry. Our bifunctional iridium complex could potentially be used in anti-cancer chemotherapy or other applications requiring rapid generation of reactive oxygen ...[more]

PMID: 33034316

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