Ontology highlight
ABSTRACT:
SUBMITTER: Leija-Salazar M
PROVIDER: S-EPMC7642339 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in neurology 20201022
<b>Background:</b> Somatic single nucleotide variant (SNV) mutations occur in neurons but their role in synucleinopathies is unknown. <b>Aim:</b> We aimed to identify disease-relevant low-level somatic SNVs in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying <i>LRRK</i>2 G2019S, whose penetrance could be explained by somatic variation. <b>Methods and Results:</b> We included different brain regions from 26 Parkinson's disease (PD), one Incidental Lewy body, th ...[more]