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Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways.

ABSTRACT: Tendinopathy is a common musculoskeletal disorder that mainly affects athletes and people of older age. Tumor necrosis factor-? (TNF-?) plays an important role in initiating tendinopathy. Tectorigenin, an extract component of Belam-canda Chinesis, possesses anti-inflammatory and anti-apoptosis activity. The present study was established to investigate the role of tectorigenin against the pathogenetic effects of TNF-? on tendon-derived stem cells (TDSCs) in vivo and in vitro. The findings indicated that TNF-? is able to induce TDSC inflammation, apoptosis, and ossification, as well as activate nuclear factor-kappa B and mitogen-activated protein kinase (MAPK). Furthermore, the results confirmed that tectorigenin is able to inhibit the TNF-?-induced inflammation, apoptosis, and ossification. Tectorigenin treatment decreases activation of NF-kappa B and MAPK signaling in TDSCs. Tectorigenin ameliorates tendinopathy in the in vivo rat model. Thus, these data reveal that tectorigenin can serve as a potential treatment for tendinopathy.

SUBMITTER: Moqbel SAA 

PROVIDER: S-EPMC7642480 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells <i>via</i> Modulating NF-Kappa B and MAPK Pathways.

Moqbel Safwat Adel Abdo SAA   Xu Kai K   Chen Zhonggai Z   Xu Langhai L   He Yuezhe Y   Wu Zhipeng Z   Ma Chiyuan C   Ran Jisheng J   Wu Lidong L   Xiong Yan Y  

Frontiers in cell and developmental biology 20201022

Tendinopathy is a common musculoskeletal disorder that mainly affects athletes and people of older age. Tumor necrosis factor-α (TNF-α) plays an important role in initiating tendinopathy. Tectorigenin, an extract component of <i>Belam-canda Chinesis</i>, possesses anti-inflammatory and anti-apoptosis activity. The present study was established to investigate the role of tectorigenin against the pathogenetic effects of TNF-α on tendon-derived stem cells (TDSCs) <i>in vivo</i> and <i>in vitro</i>.  ...[more]

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