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Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder.


ABSTRACT: Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age- and sex-matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non-suicide attempters with depression, and 109 HCs). Significant volumetric differences were found between suicidal and nonsuicidal depressed patients in several vertices: 16 in the left amygdala; 201 in the left hippocampus; 1,057 in the left putamen; and 140 in the left pallidum; 1 in the right pallidum; and 6 in the bilateral thalamus. These findings indicated subcortical alterations in LSV in components of the limbic-cortical-striatal-pallidal-thalamic circuits. Moreover, our results demonstrated that the basal ganglia was correlated with perceived stress levels, and the thalamus was correlated with suicidal ideation. We suggest that suicidality in major depressive disorder may involve subcortical volume alterations.

SUBMITTER: Kang W 

PROVIDER: S-EPMC7643352 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder.

Kang Wooyoung W   Shin Jeong-Hyeon JH   Han Kyu-Man KM   Kim Aram A   Kang Youbin Y   Kang June J   Tae Woo-Suk WS   Paik Jong-Woo JW   Lee Hae-Woo HW   Seong Joon-Kyung JK   Ham Byung-Joo BJ  

Human brain mapping 20200817 17


Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates  ...[more]

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